(July 29, 2003 - present) (2 children)

While filming the 1995 movie "Sense and Sensibility", Thompson began a relationship with her co-star Greg Wise. Commenting on how she was able to overcome her depression, she told BBC Radio Four, "Work saved me and Greg saved me. He picked up the pieces and put them together again." In 1999, the couple had a daughter, Gaia, born when Thompson was 39. The pregnancy was achieved through IVF treatment; afterwards Wise and Thompson attempted to have another child using the same method. Three years of further IVF treatment were unsuccessful.

In 2003, Thompson and Wise were married in Dunoon. The family's permanent residence is in West Hampstead, London, on the same road where Thompson lived in her youth. Also in 2003, Thompson and her husband informally adopted a Rwandan orphan and former child soldier named Tindyebwa Agaba.