"How Do I Breathe" is an R&B single by Mario. It is the first single from his third studio album Go. The single was released on May 15, 2007. It was produced by Scott Storch and Stargate. On the issue date of July 7, 2007, the single debuted on the Billboard Hot 100 at number 91. "How Do I Breathe" also debuted on the UK Singles Chart at number 30 on download sales alone, the day before the physical release of the song. It also became Mario's last charting single in the UK. The song also peaked at number 18 on the Billboard Hot R&B/Hip-Hop Songs chart. The official remix of the song features Fabolous and the second official remix features Cassidy. A rare third one features both artists and switches between beats. The song was co-written by Mario.