Over 16 different nationalities worked on the film, which was filmed in Morocco.
Temperatures soared in excess of 120 degrees Fahrenheit on the Moroccan desert set.
To get round the difficulties of shooting inside a tiny trailer, production designer Joseph C. Nemec III built a set of the inside of the trailer that was actually 30% bigger than the real thing.
The original film was threatened with an X rating, ironically this film was also threatened with a NC-17 rating.
The service station was called 'Gas Haven' which rhymes with Wes Craven.
Alexandre Aja and art director Grégory Levasseur originally planned to film in Morocco because of its similarity to the New Mexico desert. Initially the producers objected to this, for fear of terrorist attacks, but after Aja and Levasseur failed to find suitable locations in the US, they relented.
The gas station set was built on location in Morocco. It was so authentic that occasionally someone not involved in the production would stop to buy gas.
Wes Craven and producer Peter Locke originally wanted to film the new version in the exact same desert location as the 1977 film but when they went out to scout the locations they found a number of condominium developments had been built.
Make-up artist Greg Nicotero was featured as Cyst, the mutant with the halo head-gear.
Almost all of Ted Levine's actions and lines were improvised.
The mutants were created by CGI, physical effects or both. Most of the mutants with full deformations were created by prosthetic makeup. But the deformed children who were playing were digitally distorted using tracking dots on their faces. Ruby was a mixture of the two, using the tracking dots for distortion and prosthetic teeth.
The mini-series of The Ten Commandments (2006) was being filmed in Morocco nearby. The cast and crew of both productions were all staying at the same hotel.
The TV show that Big Mama is watching is Divorce Court (1999) This film's producer, Peter Locke, also produced a show called Divorce Court (1984).
The car crash scene, where the family's car and trailer are sabotaged, took 3 days to film.
The making of featurette on the DVD indicates that at some point during production, the character of Papa Jupiter was going to have a parasitic twin jutting out of his chest. The effect was scrapped for the final film, leaving him the only one of the "mutants" without any apparent mutation.
With the Aaron Stanford character, the filmmakers were looking for someone similar to Dustin Hoffman did in Straw Dogs (1971), where Hoffman was an ineffectual nerd who rises to heroism in the end and commits ghastly acts of violence. Stanford in the films also markedly physically resembles this films director, Alexandre Aja.
The photos of mutations that play during the opening credits are not of atomic mutation, but birth defects caused by the use of Agent Orange in Vietnam.
In-between takes, the production crew would stage mock-fights with various prop weapons.
The nuclear crater that Doug encounters is completely computer generated.
Ivana Turchetto, who played Big Mama, agreed to have her head shaved for $1000.
Make-up artist Gregory Nicotero was featured as Cyst, the mutant with the halo head-gear.
This version runs approximately 15 minutes longer than the original.