• The season one theme music (which on DVD can only be found on the pilot) is an arrangement of an excerpt from the song "Once In A Lifetime" by the Talking Heads.
• The New Yorkers: Rob Morrow, David Krumholtz, Judd Hirsch, Alimi Ballard and Diane Farr were all born in or around New York, NY. Although she was born in Fairfax, Virginia, Sabrina Lloyd's New York connection is in that she moved there in 1988, at the age of 18.
• When the producers prepared to pitch the series concept to the network, they prepared an elaborate presentation about the story possibilities, anticipating that the executives would wary of agreeing to such a cerebral premise. However, the network executives were immediately enthusiastic part way through the pitch that the series had good potential and insisted on production beginning immediately.
• The university Cal Sci is modeled on the California Institute of Technology (Caltech) in Pasadena, developing characters loosely based on a Caltech professor and students. Portions of the series have been filmed on the Caltech campus. Gary Lorden, the chairman of the math department at Caltech, consults for the show. The pilot episode was screened at Caltech as well, receiving a standing ovation at the end.
• Navi Rawat's character is named "Amita Ramanujan", a reference to Srinivasa Ramanujan, a self-taught Indian mathematician who worked in the first two decades of the 20th century, most notably collaborating with G.H. Hardy in number theory.

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