He is also a painter, sculptor, and photographer who currently shows his artwork in galleries in New York, Berlin, and Frankfurt.
He has appeared in seven music videos: Flat Top by Goo Goo Dolls, Cats In The Cradle by Ugly Kid Joe, Strange Currencies by R.E.M., Fake Plastic Trees by Radiohead, Violently Happy by Björk, Wicked as it Seems by Keith Richards and Judas by Lady Gaga (as Judas).
He was first discovered at a party in Los Angeles where he started screaming with giant sunglasses on, until someone asked if he wanted to be in a play.
He got his first taste of acting in the play Maps for Drowners at the Tiffany Theater on Sunset Boulevard.
In Los Angeles, he worked at a Harley Davidson shop in Venice and contributed artwork to various shows as a painter, photographer, sculptor, and video artist.
Has a titanium eye-socket, as a result of his car accident in 2005.
Lived for a time in London and Japan. Prior to getting his first acting role, he was earning $7.50 an hour working in a Venice, California, motorcycle shop.
Formerly a model for Prada
Was in a car accident in late February 2005 in Berlin, Germany, when after attending a REM concert, his driver swerved into traffic suddenly at the wrong moment, and a semi-truck struck the car in which he was riding. He was jettisoned through the windshield and landed on the sidewalk, receiving some damage to the left side of his face, for which he had to undergo surgery.
The former model Helena Christensen is his longtime girlfriend and the mother of his son. They said that they are not officially married.
Had a baby boy named Mingus Lucien Reedus with Helena Christensen, born 13 October 1999 in Helena's native country, Denmark.