• In the pilot, Roger Murtaugh is said to have recently celebrated his 50th birthday. Damon Wayans turned 56 the month the pilot aired. Danny Glover was only 41 when the original movie premiered in 1987. Keesha Sharp, who plays Trish here is 13 years younger than Wayans, whereas Darlene Love, who played Trish in the movie was 8 years older than Glover. Mel Gibson was 31 in 1987, whereas Clayne Crawford was 38 as of the air date of the pilot.
• In the third episode of season one, thieves rob an armored truck in almost the same method as the thieves from the film Heat (1995). Coincidentally, Ted Levine plays the armored truck driver in this episode, he also appeared as Bosko, one of the officers investigating the truck robbery thieves in Heat.
• In the pilot episode, in the beginning when we see Riggs' wife, Miranda, wave to the next door neighbor watering his lawn, the house behind him is the house the Murtaugh's lived in from the Lethal Weapon films.
• The Captain is named after Avery Brooks.
• Damon Wayans, who plays Murtaugh, was the protagonist of The Last Boy Scout. Both The Last Boy Scout and the original Lethal Weapon film were written by Shane Black, meaning this is the second time Damon Wayans has played a Shane Black character.

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