His parents highly encouraged him to go to college but he disagreed, and so because of that his parents kicked him out of their house and he was forced to get a job at Smoothie Hut to pay rent for his one room apartment and the bands practice space.
After seeing him perform his parents supported him and are now huge supporters.
Ranked #6 for Musics Sexiest Single Men by AOL Music in 2007.
According to PATD band member Spencer Smith, Brendon is the only member of the band that has any acting ability.
Always wears two bracelets, one that is purple and reads "Reading is Magic," and one that is white, blue, red, and green striped.
One of his favorite songs is "In Your Eyes" by Peter Gabriel.
When he was around 11 he dressed up as Sub-Zero from Mortal Kombat (1995) for Halloween.
He idolizes Freddie Mercury.
He is the 2nd youngest boy of four boys and has a sister named Kara.
He is a vegetarian borderline vegan.
He was named one of Spin.com's Hottest Stars Under 25 in 2006.
He also plays keyboard, accordion, piano, organ, cello, bass, drums and guitar.
Brendon provided backing vocals for Fall Out Boy's "7 Minutes In Heaven (Atavan Halen)" and "A Little Less Sixteen Candles, A Little More Touch Me.".
Brendon along with Panic! band member, Spencer Smith, appear in Fall Out Boy's "A Little Less Sixteen Candles, A More Touch Me" music video.
When asked what superpower Brendon would have he said he would have invisibility. Not for just being invisible though, because your clothes can still be seen, but so that he could walk around naked without been seen, since walking around naked isn't socially acceptable.
Brendon likes to walk around naked at home.
Brendon almost went to college in Arizona, but his bandmates talked him out of it.
Brendon has a bracelet that says "RYAN" (the name of his bandmate. Ryan also has a bracelet that says "BRENDON")
Brendon has an addiction to the energy drink Red Bull.
Brendon likes to race motorcycles.
Brendon has a tattoo of piano keys on his forearm
Brendon plays 8 instruments: guitar, piano, cello, accordian, bass, drums, keyboard and organ.